Thomas A. Collet, President, CEO, and Co-founder Phrixus
Pharmaceuticals, Inc.


Thomas A. Collet is a serial entrepreneur, whose companies have raised more than $35 million in seed and early stage capital. Rubicon Genomics, his first start-up, continues to grow rapidly in the genomic sample prep space. Neural Intervention Technologies, a company that he co-founded and that developed a product for hemorrhagic stroke, was sold to W.L. Gore in 2006. ProNAi Therapeutics, a cancer therapy company where he was the first CEO, filed to go public in 2015. Earlier, Collet was a general partner at Tullis-Dickerson, helping manage a $40 million seed and early stage fund. He also was a vice president at Monsanto, where he helped start Integrated Protein Technologies, the company’s internal venture for the production of pharmaceutical proteins in green plants. He began his career at McKinsey, working with clients in technology-focused business units of Fortune 500 companies.

Degrees: Ph.D., Massachusetts Institute of Technology; postdoctoral fellow, Scripps Research Institute, La Jolla, CA.

Bruce Markham, Chief Scientific Officer, VP R&D, and Co-founder Phrixus Pharmaceuticals, Inc.


In addition to Phrixus responsibilities, Bruce Markham serves as mentor-in-residence in the Office of Technology Transfer at the University of Michigan and on the advisory board of Cytometix. Prior to Phrixus, he was a research fellow at Pfizer in the cardiovascular area, where he brought six compounds to the clinical candidate stage and was a member of the licensing team. He began his career as an associate professor of physiology at the Medical College of Wisconsin, as well as an established investigator at the American Heart Association, and trained in molecular genetics at the University of Arizona.

Degrees: B.A., Western Michigan University; Ph.D., Michigan State University.

James Symons, VP Clinical and Regulatory Affairs


James Symons began his clinical career at Parke-Davis, later Pfizer, where he had primary responsibility for a number of programs that resulted in New Drug Application (NDA) approvals and led efforts for the submission of additional NDAs in the areas of asthma and vaginal atrophy. Symons began his career at the Jackson Laboratory, Bar Harbor, ME, where he conducted research in behavior genetics and he was part of the first program granted funds to develop mouse models of aging.

Degrees: M.S. physiological psychology, M.S. biostatistics and research design, Ph.D. epidemiologic science, University of Michigan, Ann Arbor.